組織・神経解剖学教室と合同で、毎週月曜日午前９時３０分から当教室会議室(2316)において抄読会を行
っています。世界の一流誌に投稿された最新の論文を順番に解説し、互いに議論することによって、最新の
神経科学知識を習得し、今後の研究に生かすことができます。現在、組織・神経解剖学教室ならびに当教
室の教官、研究員、大学院生に加えて、器官・細胞生理学教室から塩谷先生が抄読会に参加しています。
興味のある方は自由に参加して下さい。
2011年
2010年
| 3.14. | 水田 | Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Nature 465, 1070-1074 (2010) |
| 2.21. | 蒋 | Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites. Nature 418, 85-89 (2002) |
| 2.14. | 川崎 | Acid sensing by the Drosophila olfactory system. Nature 468, 691-695 (2010) |
| 1.24. | 熊本 | Channel-mediated tonic GABA release from glia. Science 330, 790-796 (2010) |
| 1.18. | 八坂 | Targeting single neuronal networks for gene expression and cell labeling in vivo. Neuron 67,562-574 (2010) |
| 10.28. | 上村（聡） | Contribution of the chemokine (C-C Motif) Ligand 2 (CCL2) to mechanical hypersensitivity after surgical incision in rats. Anesthesiology 112,1250-1258 (2010) |
| 9.27. | 井上 | The cell and peripheral representation of sodium taste in mice. Nature 464, 297-301 (2010) |
| 6.7. | 村田 | Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. Journal of Neuroscience 29. 2259-2271 (2009) |
| 5.31. | 楊 | 中国で行っていた研究の紹介 |
| 5.10. | 朴 | Injury-induced mechanical hypersensitivity requires C-low threshold mechanoreceptors. Nature 462, 651-655 (2009) |
| 4.26. | 岳 | A critical role for alpha4-beta-delta GABAA receptors in shaping learning deficits at puberty in mice. Science 327, 1515-1518 (2010) |
| 4.19. | 藤田 | Molecular basis of infrared detection by snakes. Nature 464, 1006-1011 (2010) |
| 4.12. | 塩谷 | β2-Adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science 327, 1653-1657 (2010) |
| 3.23. | 水田 | Dendritic encoding of sensory stimuli controled by deep cortical internaurons. Nature 457, 1137-1141 (2009) |
| 3.2. | 熊本 | Long-term potentiation depends on release of D-serine from astrocytes. Nature 463, 232-236 (2010) |
| 2.22. | 八坂 | Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons. Journal of Neuroscience 29. 13202-13209 (2009) |
| 2.16. | 上村（聡） | Gabapentin acts within the locus coeruleus to alleviate neuropathic pain. Anesthesiology 109. 1077-1084 (2008) |
| 1.25. | 井上 | Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. Science 325. 760-764 (2009) |
| 1.18. | 村田 | Expression and developmental regulation of oxytocin (OT) and oxytocin receptors (OTR) in the enteric nervous system (ENS) and intestinal epithelium. Journal of comparative neurology 512, 256-270 (2009) |
| 1.12. | 朴 | Regulation of cortical microcircuits by unitary GABA-mediated volume transmission. Nature 461, 1278-1281 (2009) |
| 12.14. | 岳 | Sleep deprivation impairs cAMP signaling in the hippocampus. Nature 461, 1122-1125 (2009) |
| 12.14. | 藤田 | Induction of synaptic long-term potentiation after opioid withdrawal. Science 325. 207-210 (2009) |
| 11.30. | 塩谷 | A modular switch for spatial Ca2+ selectivity in the calmodulin regulation of CaV channels. Nature 451, 830-834 (2008) |
| 11.17. | 水田 | Distinct contributions of NaV1.6 and NaV1.2 in action potential initiation and backpropagation. Nature neuroscience 12, 996-1002 (2009) |
| 10.5. | 青山 | Cellular basis of itch sensation. Science 325. 1531-1534 (2009) |
| 9.28. | 熊本 | Functional proteimics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science 323. 1313-1319 (2009) |
| 9.1. | 八坂 | 脊髄後角膠様質細胞の分類ー発火パターン、細胞の形態、神経伝達物質の種類、神経修飾物質に対する反応を用いてー（グラスゴウ大学で行った研究の紹介） |
| 7.6. | |
Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system. Pain 144, 84-94 (2009) |
| 6.15. | |
Inhibitory effect of oxytocin on accelerated colonic motility induced by water-avoidance stress in rats. Neurogastroenterology & Motility Early View, Date: March 2009 |
| 6.8. | |
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445, 541-545 (2007) |
| 5.25. | |
Synaptic depression enables neuronal gain control. Nature 457, 1015-1018 (2009) |
| 5.18. | |
Nicotine binding to brain receptors requires a strong cation-pai interaction. Nature 458, 534-537 (2009) |
| 5.11. | |
Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation. J Physiol 587, 1087-1100 (2009) |
| 4.14. | |
The hallucinogen N,N-Dimethyltryptamine (DMT) is an endogenous sigma-1 receptor regulator. Science 323, 934-937 (2009) |
| 4.6. | |
Synaptic corelease of ATP and GABA in cultured spinal neurons. Nature Neuroscience 2, 241-245 (1999) |
| 3.30. | |
TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455, 1210-1215 (2008) |
| 3.23. | |
The beta-glucuronidase klotho Hydrolyzes and activates the TRPV5 channel. Science 310, 490-493 (2005) |
| 3.2. | |
Inhibitory postsynaptic potentials in motoneurons remain depolarizing after neonatal spinal cord transection in the rat. J Neurophysiol 96, 2274-2281 (2006) |
| 2.23. | |
Activity-dependent regulation of inhibitory synapse development by Npas4. Nature 455, 1198-1204 (2008) |
| 2.17. | |
A heat-sensitive TRP channel expressed in keratinocytes. Science 296, 2046-2049 (2002) |
| 2.2. | |
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 432, 723-730 (2004) |
| 1.26. | |
An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nature Neuroscience 9, 93-98 (2006) |
| 12.22. | |
A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiology 117, 500-544 (1952) |
| 10.20. | |
A stomatin-domain protein essential for touch sensation in the mouse. Nature 445, 206-209 (2007) |
| 10.14. | |
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving. Nature 454, 118-121 (2008) |
| 10.6. | |
The cell and molecular basis of mechanical, cold, and inflammatory pain. Science 453, 1253-1258 (2008) |
| 9.16. | |
Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature 453, 1253-1258 (2008) |
| 9.8. | |
An internal thermal sensor controlling temperature preference in Drosophila. Nature 454, 217-220 (2008) |
| 7.28. | |
CD38 is critical for social behaviour by regulating oxytocin secretion. Nature 446, 41-45 (2007) |
| 6.16. | |
Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science 319: 1536-1539 (2008) |
| 5.12. | |
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science 318, 815-817 (2008) |
| 4.21. | |
Electric ｆields due to synaptic currents sharpen excitatory transmission.Science 319, 1845-1849 (2008) |
| 4.14. | |
Protein synthesis and neurotrophin-dependent structural plasticity of single dendritic spines. Science 319, 1683-1687 (2008) |
| 4.7. | |
The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. Journal of Physiology 116, 497-506 (1952) |
| 3.10. | |
The menthol receptor TRPM8 is the principle detector of environmental cold. Nature 448, 204-208 (2007) |
| 3.3. | |
Removal of phospho-head groups of membrane lipids immobilizes voltage sensors of K+ channels. Nature 451, 826-829 (2008) |
| 2.25. | |
TRPC channel activation by extracellular thioredoxin. Nature 451, 69-72 (2007) |
| 2.12. | |
ATP is a mediator of chemosensory transduction in the central nervous system. Nature 436, 108-111 (2005) |
| 1.29. | |
Reversal of pathological pain through specific spinal GABAA receptor. Nature 451, 330-334 (2008) |
| 1.15. | |
The origin of spontaneous activity in the developing auditory system. Nature 450, 50-56 (2007) |
| 12.25. | |
A synaptic memory trace for cortical receptive field plasticity. Nature 450, 425-429 (2007) |
| 12.17. | |
The components of membrane conductance in the giant axon of Loligo. Journal of Physiology 116, 473-496 (1952) |
| 12.11. | |
A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448, 700-703 (2007) |
| 11.28. | |
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers. Nature 449, 607-610 (2007) |
| 10.9. | |
Molecular and cellular mechanisms of general anaesthesia. Nature 367, 607-614 (1994) |
| 10.2. | |
P2X7 receptor inhibition improves recovery after spinal cord injury. Nature Medicine 10, 821-827 (2004) |
| 8.21. | |
Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures. Nature 447, 855-858 (2007) |
| 7.10. | |
SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature 447, 321-325 (2007) |
| 6.4. | |
Endocannabinoid-mediated rescue of striatal LTD and motor deficits in Parkinson’s disease models. Nature 445, 643-647 (2007) |
| 5.28. | |
Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons. Science 316, 758-761 (2007) |
| 5.21. | |
Opioids block long-term potentiation of inhibitory synapses. Nature 446, 1086-1090 (2007) |
| 5.7. | |
Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. Journal of Physiology 116, 449-472 (1952) |
| 4.23. | |
UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446, 1091-1095 (2007) |
| 4.2. | |
Two modes of fusion pore opening revealed by cell-attached recordings at a synapse. Nature 444, 102-105 (2006) |
| 3.12. | |
Ｃａ2+ entry through plasma membrane IP3 receptors. Science 313, 229-233 (2006) |
| 3.6. | |
Axonal site of spike initiation enhance auditory coincidence detection.Nature 444, 1069-1072 (2006) |
| 2.19. | |
Direct activation of the ion channel TRPA1 by Ca2+. Nature Neuroscience 10, 277-279 (2007) |
| 1.30. | |
Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor. Nature 444, 106-109 (2006) |
| 1.23. | |
Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal Brain during delivery. Science 314, 1788-1792 (2006) |
| 12.19. | |
Measurement of current-voltage relations in the membrane of the giant axon of Loligo. Journal of Physiology 116, 424-448 (1952) |
| 12.12. | |
Structural and functional diversities among μ-conotoxins targeting TTX-resistant sodium channels. Biochemistry 45, 3723-3732 (2006) |
| 11.28. | |
Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science 312,1659-1662 (2006) |
| 11.28. | |
Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature 444, 208-212 (2006) |
| 11.21. | |
Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptors. Nature 443, 705-708 (2006) |
| 10.2. | |
Potentiation of cortical inhibition by visual deprivation. Nature 443, 81-84 (2006) |
| 9.25. | |
Synaptic scaling mediated by glial TNF-a. Nature 440, 1054-1059 (2006) |
| 9.11. | |
Enzymatic activation of voltage-gated potassium channels.
Nature 442, 696-699 (2006)
|
| 7.3. | |
A voltage sensor domain protein is a voltage-gated proton channel.
Science 312, 589-592 (2006)
|
| 5.29. | |
Ischemia opens neuronal gap junction hemichannels.
Science 312, 924-927 (2006)
|
| 5.22. | |
Protease-activated receptor 2 expression in trigeminal neurons innervating
the rat nasal mucosa. Neuropeptides 39, 461-466 (2005) |
| 5.16. | |
Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits.
Science 311, 233-235 (2006) |
| 5.8. | |
Noxious cold ion channel TRPA1 is activated by pungent compounds and
bradykinin. Neuron 41, 849-857 (2004) |
| 4.24. | |
GABA regulates synaptic integration of newly generated neurons in the adult
brain. Nature 439, 589-593 (2006) |
| 3.14. | |
Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature
438, 1022-1025 (2005) |
| 2.27. | |
SLC24A5, a putative cation exchanger, affects pigmentation in Zebrafish and
Humans. Science 310, 1782-1786 (2005) |
| 2.20. | |
ATP signaling is crucial for communication from taste buds to gustatory
nerves. Science 310, 1495-1499 (2005) |
| 1.30. | |
NMDA receptors are expressed in oligodendrocytes and activated in
ischaemia. Nature 438, 1162-1166 (2005) |
| 1.23. | |
Pungent products from garlic activate the sensory ion channel TRPA1.
PNAS 102, 12248-12252 (2005)
|
| 1.16. | |
BDNF from microglia causes the shift in neuronal anion gradient underlying
neuropathic pain. Nature 438, 1017-1021 (2005) |
| 1.10. | |
Morphine reward in dopamine-deficient mice.
Nature 438, 854-857 (2005)
|
| 12.26. | |
Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid
mixtures. Science 310, 1678-1680 (2005) |
| 12.13. | |
Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels.
PNAS 100, 501-505 (2002) |
| 11.28. | |
Retrograde signaling by Syn 4 induces presynaptic release and synapse-
specific growth. Science 310, 858-863 (2005) |
| 11.7. | |
Astrocytic purinergic signaling coordinates synaptic networks. Science 310,
113-116 (2005) |
| 10.3. | |
Spike-timing-dependent synaptic plasticity depends on dendritic location.
Nature 434, 221-225 (2005) |
| 9.26. | |
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors. Nature 436, 103-107 (2005) |
| 9.12. | |
Vasopressin and oxytocin excite distinct neuronal populations in the central
amygdala. Science 308, 245-248 (2005) |
| 9.5. | |
An endocannabinoid mechanism for stress-induced analgesia. Science 307,
1468-1472 (2005) |
| 7.11. | |
Reduced sleep in Drosophila Shaker mutants. Nature 434, 1087-1092 (2005)
Underwater bipedal locomotion by octopuses in disguise. Science 307, 1927 (2005) |
| 6.13. | |
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor
in the skin. Science 307, 1468-1472 (2005) |
| 6.6. | |
Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP. Nature 434, 763-767 (2005) |
| 3.28. | |
Vesicle endocytosis requires dynamin-dependent GTP hydrolysis at a fast
CNS synapse. Science 307, 124-127 (2005) |
| 3.7. | |
Proteinase-activated receptor 2-mediated potentiation of transient
receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-99 (2004) |
| 2.21. | |
Conditional transgenic suppression of M channels in mouse brain reveals
functions in neuronal excitability, resonance and behavior. Nature Neuroscience 8, 51-59 (2005) |
| 2.14. | |
Structural basis of long-term potentiation in single dendritic spines. Nature
429, 761-766 (2004) |
| 1.24. | |
Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434-439 (2000) |
| 1.17. | |
Developmental switch from GABA to glycine release in single central synaptic terminals. Nature Neuroscience 7, 17-23 (2004) |
| 12.20. | |
Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids. Nature 431, 312-316 (2004) |
| 12.6. | |
Cleavage of proBDNF by tPA/Plasmin is essential for long-term hippocampal
plasticity. Science 306, 487-491 (2004) |
| 11.29. | |
Therapeutic silencing of an endogenous gene by systemic administration of
modified siRNAs. Nature 432, 173-178 (2004) |
| 11.22. | |
Routing of spike series by dynamic circuits in the hippocampus. Nature 429,
717-723 (2004) |
| 11.15. | |
Regulation of protein synthesis by miniature synaptic events. Science 304, 1979-1983 (2004)
|
| 10.12. | |
Rapid BDNF-induced retrograde synaptic modification in a developing
retinotectal system. Nature 429, 878-883 (2004) |
| 9.13. | |
Agonist-independent modulation of N-type calcium channels by ORL1
receptors. Nature Neuroscience 7, 118-125 (2004) |
| 9.6. | |
The principle of temperature-dependent gating in cold-and heat-sensitive
TRP channels. Nature 430, 748-754 (2004) |
| 8.30. | |
GlyR a3: An essential target for spinal PGE2-mediated inflammatory pain
sensitization. Science 304, 884-887 (2004) |
| 8.23. | |
Functional conversion between A-type and delayed rectifier K channels by membrane lipids. Science 304, 265-270 (2004) |
| 6.21. | |
Retrograde activation of presynaptic NMDA receptors enhances GABA
release at cerebellar interneuron-Purkinje cell synapses. Nature Neuroscience 7, 525-533 (2004) |
| 6.14. | |
Role of NMDA receptor subtypes in governing the direction of hippocampal
synaptic plasticity. Science 304, 1021-1024 (2004) |
| 5.17. | |
Enhanced synaptic plasticity in newly generated granule cells of the adult
hippocampus. Nature 429, 184-187 (2004) |
| 5.10. | |
Integration of quanta in cerebellar granule cells during sensory processing.
Nature 428, 856-859 (2004) |
| 4.26. | |
Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce m-opioid receptor internalization in the rat spinal cord. Journal of Neuroscience 23, 9171-9184 (2003) |
| 4.12. | |
Facilitation of spinal NMDA receptor currents by spillover of synaptically released glycine. Science 300, 2094-2097 (2003) |
| 4.5. | |
An ATP-gated ion channel at the cell nucleus. Nature 420, 42 (2002) |
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